Holly Ferling returns to the squad while Annabel Sutherland will miss due to VCE school commitments.
The Stars will be looking for its first win of the season after suffering consecutive losses to the Hobart Hurricanes on opening weekend.
Melbourne Stars 13-player squad
Elyse Villani (c)
Mignon du Preez
Melbourne Stars v Sydney Sixers
Saturday, October 26
Hurstville Oval, Hurstville @ 2pm (AEDT)
Melbourne Stars v Sydney Thunder
Sunday, October 27
Bankstown Oval, Bankstown @ 2pm (AEDT)