Jackson Coleman and Jonathan Merlo will come into the squad for Sam Elliott and Nathan Coulter-Nile who is being rested.
The Stars are currently sitting on top of the table with seven wins and one loss while the Sixers are second with six wins.
Melbourne Stars 13-player squad v Sixers
Glenn Maxwell (c)
Melbourne Stars v Sydney Sixers
Sunday, January 12
MCG @ 7.10pm
Watch live on Seven and Fox Cricket